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Supporting this hypothesis, we demonstrate that GLP-1 receptor-mediated targeting of MK-801 effectively avoids other adverse effects associated with MK-801 monotherapy, including hyperthermia and hyperlocomotion

However, these gastrointestinal activities are also the reason why subjects treated with GLP-1-based agents occasionally experience nausea

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Liana Billings, an endocrinologist at Endeavor Health NorthShore Hospitals in Illinois, highlighted the benefits of these drugs for people with type 2 diabetes at the 2024 European Association for the Study of Diabetes (EASD) annual conference

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Treatment often requires a multidisciplinary approach, including pharmacological interventions (e.g., anticonvulsants, muscle relaxants), non-pharmacological therapies (e.g., acupuncture, hypnosis), and, in severe cases, surgical interventions such as vagus nerve stimulation